Verfasst: 23. Aug 2020 23:18
wenn man sich nicht gerade 'Omni Whole-Food' ernährt, hat man als Omni ja vermutlich auch einen deutlich höheren Intake, weil das da in vielem Processed Food zugesetzt ist.
Na superhuman vegetable hat geschrieben: ↑16. Sep 2020 20:45Neue Studie zu Sucralose: https://ergo-log.com/sucralose-reduces- ... ivity.html
Bei gleichzeitiger Einnahme mit schnellen KH senkt Sucralose demnach die Insulinsensitivität, was langfristig Diabetes begünstigen könnte.
So, if we simply assume that the reported changes are accurate, one approach to answering the ultimate question, i.e "Do I have to avoid products that contain sucralose?", is to compare the 18% decrease in insulin sensitivity Romo-Romo et al. observed in their study with changes that have been observed in other contexts. Here are three contexts come to mind...
T2DM patients, for example, see improvements of the insulin sensitivity in the range of ~80% in response to treatment with a GLP-1 analogs (Zander 2002 | this study is also relevant because scientists speculate that the effects may be related to GLP1, the release of which is increased upon co-exposure of sucralose and glucose, Temizkan 2015), while ...
sleep restriction acutely reduces the insulin sensitivity of healthy subjects by 13% per hour that's lost (the coefficient is based on reductions from 8 to 5 hours in Wong 2015), and
two-weeks of HIIT training (15 min of exercise; 3x per week; 4–6 × 30-s cycle sprints) improves Si in healthy young men by 23% (Babraj 2009).
In theory, the -18% reduction in insulin sensitivity is thus in a range that physical activity or improved sleep habits could undo, and miles apart from what would turn a healthy human being into a diabetic.
Der Schlusssatz ist bedenkenswert. Auch wenn Sucralose bei manchen Menschen evtl. zu einem Anstieg führt, ist Sucralose gegenüber konventionellen Süßungsmitteln immer noch die bessere Wahl.Estimate: Only one in 116 subjects will definitely see significant reductions in insulin sensitivity
That sucralose does not pave the way to certain type II diabetes becomes even more obvious when we calculate another statistical value, the Number Needed to Treat (NNT), i.e. the number of people you would have to put on sucralose for one week to see a deterioration of the insulin sensitivity.
To this ends, we will return to our previous example and assume - as we did before - that your individual risk of experiencing a reduction in insulin sensitivity over the next two weeks is 0.2%. If we use this assumption and the odds ratio to calculate the NNT, the number we get is 116. In other words: In our example, only 1 in 116 people (see Figure 2) who consume sucralose for two weeks will 'definitely' see a significant decrease in insulin sensitivity solely due to the consumption of 2.25mg/kg sucralose per day (please, don't forget that these numbers are just meant to illustrate the results, they are based on an estimation of the risk to experience a reduction in insulin sensitivity over two weeks in healthy individuals, and must be regarded as contextualizations that shall help you understand the significance of the results of the scientists' odds analysis, and not as a quantitatively precise result of the study at hand).
While you're waiting for these studies to be conducted and published, it may, in fact, make sense to monitor and limit your personal sucralose intake. Unfortunately, the contemporary labeling regulations don't require that the food and supplement industry disclose the exact amounts of sucralose (and other sweeteners, aromas, etc.) in a product on the nutrition label. Hence, you will ultimately have to decide whether the (in absolute terms) small risk increase warrants cutting out all products that contain sucralose - a decision of which I hope that the article at hand will help you with. Ah, and I don't have to emphasize that replacing 100mg of sucralose in your diet with the 60g of sugar (sucrose) that produce the same sweet sensation wouldn't be the best strategy to avoid reductions in insulin sensitivity - do I?
Zu spät!human vegetable hat geschrieben: ↑13. Jan 2021 12:07
Insofern noch kein Grund den Kilopurzler (oder wie der Drink auch immer heißt) im Klo zu entsorgen.
Mal eine Frage: Habe mir immer mal für die Arbeit einen Shake mit 50-80g gemacht für über den Tag, danach war mir jetzt schon 3x etwas schwummrig.